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Perimenopause

What We Learned at The Menopause Society 2025 Annual Meeting And Why It Actually Matters for Your Health

Amy Divaraniya
Amy Divaraniya

The latest menopause research from 1,600+ healthcare professionals reveals surprising insights about brain fog, weight changes, and hormone therapy that could change how you navigate midlife.

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Nov 11, 2025
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The Menopause Society 2025 Annual Meeting attendees at Hyatt Regency Orlando conference hall discussing latest menopause research
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Nov 12, 2025
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The latest menopause research from 1,600+ healthcare professionals reveals surprising insights about brain fog, weight changes, and hormone therapy that could change how you navigate midlife.

Perimenopause
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The latest menopause research from 1,600+ healthcare professionals reveals surprising insights about brain fog, weight changes, and hormone therapy that could change how you navigate midlife.

This October, the Oova team joined thousands of clinicians, scientists, and innovators at The Menopause Society's 2025 Annual Meeting in Orlando, with its theme "Optimizing Health and Longevity at Menopause and Beyond." The energy wasn't just electric, it was transformative. From breakthrough research on "menopause brain" to new understanding of metabolic changes, what we learned challenges everything we thought we knew about this transition.

Here are the most actionable takeaways that could change your menopause journey.

1. Your Brain Isn't Breaking, It's Actually Rewiring (And That's Good News)

The Research: If you've forgotten why you walked into a room or lost a word mid-sentence, you're experiencing what Dr. Pauline Maki from the University of Illinois at Chicago calls temporary cognitive changes tied to fluctuating estrogen, not permanent decline.

The Science: New research shows that vasomotor symptoms (hot flashes) relate more strongly to memory issues when measured objectively rather than by self-report. Dr. Rebecca Thurston's work reveals that frequent hot flashes connect to changes in vascular health and stress response, creating that "brain fog" feeling.

What You Can Do:

  • Track your hot flash patterns, cognitive symptoms and hormone patterns together
  • Consider early hormone therapy if appropriate, it may support memory by preserving metabolism in the hippocampus 
  • Focus on vascular health through exercise and stress management
  • Know that these changes are typically temporary during the transition

2. Perimenopause Is Your Cardiovascular Wake-Up Call

The Research: Sessions on cardiovascular outcomes during the menopause transition highlighted that midlife represents both vulnerability and opportunity for heart health.

The Science: As estrogen declines:

  • Lipoprotein(a) levels spike
  • Small-vessel dysfunction becomes more common
  • Abdominal fat storage increases
  • Managing hot flashes may actually improve cardiovascular outcomes

What You Can Do:

  • Schedule a comprehensive cardiac screening in your 40s
  • Monitor blood pressure and cholesterol more frequently
  • Consider newer therapies like GLP-1s and SGLT2 inhibitors with your doctor
  • Don't ignore vasomotor symptoms, treating them helps your heart too

3. Bone Loss Starts Earlier Than Your Doctor Might Check

The Research: Dr. Michael McClung's presentation revealed that significant bone loss begins 1-2 years before your final period,  long before most women get their first DEXA scan.

The Numbers:

  • Spinal bone density can drop 10% within 5 years post-menopause
  • Most women don't get screened until their 60s
  • Early intervention is far more effective than later treatment

What You Can Do:

  • Request a baseline DEXA scan in your early 40s, not 60s
  • Start strength training now (seriously, today)
  • Ensure adequate calcium and vitamin D intake
  • Discuss bone-protective strategies during perimenopause

4. Weight Gain Has New Rules (And New Solutions)

The Research: Dr. Monica Christmas's Menopause 101 course covered managing menopause symptoms for optimal weight loss, while sessions on "Nutrient-Stimulated Hormone-Based (NuSH) Therapeutics" revealed new treatment approaches.

The Science Behind Midlife Weight Changes:

  • Estrogen loss drives fat storage to the abdomen
  • Sleep disruption spikes ghrelin (hunger hormone)
  • Metabolism genuinely changes, it's not "all in your head"
  • Stress compounds everything

What You Can Do:

  • Prioritize sleep quality over everything else
  • Add resistance training 3x weekly (cardio alone won't cut it)
  • Consider medical support: newer GLP-1 medications show promise
  • Stop blaming yourself, this is biology, not willpower

Read: Complete Guide to Losing Weight in Perimenopause

5. Hormone Therapy Is Getting Personalized (Finally)

The Research: New safety data on nonhormonal treatments like elinzanetant showed excellent tolerability over one year Contemporary OB/GYN, while traditional hormone therapy guidance continues to evolve.

Key Updates:

  • Micronized progesterone remains safest for uterine protection
  • Estrogen therapy after surgical menopause is protective for bone and heart health, even in BRCA carriers
  • Testosterone therapy helps with low desire but only at physiologic doses
  • Timing matters — early initiation shows more benefits! 

What You Can Do:

  • Work with a menopause-certified practitioner
  • Discuss your complete health history and family risk factors
  • Consider both hormonal and non-hormonal options
  • Remember: there's no one-size-fits-all approach

6. The Future Is Whole-Woman Care

The Big Picture: The Presidential Symposium on "Mind, Brain, and Body Connections" emphasized how hormone-brain interactions, trauma, the gut-brain axis, and mental health all intersect during menopause.

From discussions on Indigenous health to the microbiome's role, the message was clear: menopause isn't just hormonal: it's physical, emotional, metabolic, and social.

The Bottom Line: Data-Driven, Personalized Care Is Here

With over 500 women in brain health studies alone and 234,000 in metabolic research presented at the meeting, we're moving beyond guesswork. The future of menopause care is:

  • Individualized based on your unique biology
  • Integrated across all body systems
  • Informed by massive datasets
  • Inclusive of diverse experiences

At Oova, this validates our mission: quantifying hormonal transitions with precise, at-home testing so you have data you can trust and care that meets you where you are.

Ready to take control of your menopause journey? Start tracking your hormones today with Oova's at-home testing.

About the author

Amy Divaraniya
Dr. Aparna (Amy) Divaraniya is the Founder and CEO of Oova. She has over 10 years experience working in data science and a PhD in Biomedical Sciences. In 2017, Amy pivoted to women's healthcare after facing her own fertility struggles. Amy started Oova to give women control over their fertility by making high-quality hormone testing more accessible.

Sources

Information based on presentations at The Menopause Society 2025 Annual Meeting, October 21-25, 2025, Orlando, FL. Full abstracts will be published in the December 2025 issue of Menopause.

  • Christmas, Monica M. "Menopause 101 Course." The Menopause Society 2025 Annual Meeting, 21 Oct. 2025, Hyatt Regency Orlando, Orlando, FL. Conference presentation.
  • Faubion, Stephanie S., et al. "Menopause and the Workplace: Consensus Recommendations from The Menopause Society." Menopause, vol. 31, no. 9, Sept. 2024, pp. 741-749.
  • Garrison, Jennifer. "Reframing Longevity and Extending Health Span in Women." The Menopause Society 2025 Annual Meeting, 23 Oct. 2025, Hyatt Regency Orlando, Orlando, FL. Keynote Address.
  • Garrison, Jennifer, et al. "Ovarian Function and Female Aging." Buck Institute for Research on Aging, 2025, www.buckinstitute.org/lab/garrison-lab/.
  • Kinney, Cheryl Cox, chair. "Optimizing Health and Longevity at Menopause and Beyond." The Menopause Society 2025 Annual Meeting Scientific Program, The Menopause Society, 21-25 Oct. 2025, menopause.org/annual-meetings/2025-annual-meeting/scientific-program.
  • Maki, Pauline M. "Three Symptoms Linked to Cognitive Complaints." The Menopause Society Consumer Video and Podcast Series, 2025, menopause.org/patient-education/consumer-videos-podcasts.
  • Maki, Pauline M., and Rebecca C. Thurston. "Menopause and Brain Health: Hormonal Changes Are Only Part of the Story." Frontiers in Neurology, vol. 11, 23 Sept. 2020, doi:10.3389/fneur.2020.562275.
  • McClung, Michael. "Perimenopause and Bone Health." The Menopause Society 2025 Annual Meeting, 21-25 Oct. 2025, Hyatt Regency Orlando, Orlando, FL. Conference presentation.
  • McClung, Michael R. "Did You Know Half of Bone Loss Happens Before Menopause?" Interview. Contemporary OB/GYN, 28 Oct. 2025, www.contemporaryobgyn.net/shorts/did-you-know-half-of-bone-loss-happens-before-menopause.
  • Simon, James A., et al. "Pooled US Safety Data for Elinzanetant in Menopausal Women with Vasomotor Symptoms." The Menopause Society 2025 Annual Meeting, Oct. 2025, Hyatt Regency Orlando, Orlando, FL. Conference presentation.
  • Soares, Claudio N. "Mind, Brain, and Body Connections: How Does That Really Work?" The Menopause Society 2025 Annual Meeting Presidential Symposium, 22 Oct. 2025, Hyatt Regency Orlando, Orlando, FL. Conference presentation.
  • Splinter, Tallinn, et al. "Earlier Menopause and Reduced Cardiac Function Can Take a Toll on Brain Health." The Menopause Society, 21 Oct. 2025, menopause.org/press-releases/earlier-menopause-and-reduced-cardiac-function-can-take-a-toll-on-brain-health.
  • The Menopause Society 2025 Annual Meeting: A Primary Care Preview. Patient Care Online, 11 Oct. 2025, www.patientcareonline.com/view/the-menopause-society-2025-annual-meeting-a-primary-care-preview.
  • The Menopause Society Prepares to Convene in Orlando for 2025 Annual Meeting. Contemporary OB/GYN, 14 Oct. 2025, www.contemporaryobgyn.net/view/the-menopause-society-prepares-to-convene-in-orlando-for-2025-annual-meeting.
  • Thurston, Rebecca C. "Vasomotor Symptoms and Cardiovascular Health: Findings from SWAN and the MsHeart/MsBrain Studies." Climacteric, vol. 27, no. 1, 2024, pp. 75-80.
  • Thurston, Rebecca C., et al. "Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN." Journal of the American Heart Association, vol. 10, no. 3, 2 Feb. 2021, doi:10.1161/JAHA.120.017416.
  • Thurston, Rebecca C., et al. "Menopausal Vasomotor Symptoms and White Matter Hyperintensities in Midlife Women." Neurology, vol. 100, no. 2, 10 Jan. 2023, pp. e133-e141.
perimenopause-periods
Should I still see my gynecologist if my periods are just "weird" but not painful?
Yes. Annual visits remain important during perimenopause. Your provider can help determine if your "weird" periods are typical perimenopause changes or something requiring attention. They can also discuss management options to improve your quality of life.
perimenopause-periods
How long do irregular periods last before menopause?
Irregular perimenopause periods typically last 4 to 8 years before your final period, though this varies greatly. Some women experience irregularity for just a few months, while others have irregular periods for over a decade before reaching menopause.
perimenopause-periods
Is it normal to have two periods in one month during perimenopause?
Yes, this can happen, especially in early perimenopause when cycles shorten. You might have a 21 day cycle, meaning you could have a period at the beginning and end of the same calendar month. Track these patterns to distinguish between short cycles and abnormal bleeding.
perimenopause-periods
Why are my periods suddenly so heavy in my 40s?
Heavy perimenopause periods often result from estrogen dominance. When progesterone drops but estrogen remains high, your uterine lining builds up more than usual, causing heavier bleeding when it sheds. This is common in perimenopause but should be evaluated if it affects your daily life.
perimenopause-periods
Can I still get pregnant if my periods are irregular during perimenopause?
Yes. As long as you're having periods, even irregular ones, you may still be ovulating. Pregnancy is possible until you've gone 12 full months without any period. If you don't want to become pregnant, continue using contraception throughout perimenopause.
perimenopause-and-weight-gain
Can you prevent perimenopause weight gain completely?
While you may not prevent all weight changes during perimenopause, you can minimize gain through proactive strategies. Starting strength training before perimenopause, maintaining consistent sleep habits, and managing stress can help your body adapt to hormonal changes more smoothly. Remember, some body changes during this transition are normal and healthy.
perimenopause-and-weight-gain
At what age does perimenopause weight gain typically start?
Perimenopause weight gain can begin in your late 30s or early 40s, often coinciding with the first hormonal changes. Many women notice gradual changes starting 5 to 10 years before their final period. The timing varies greatly based on genetics, lifestyle, and overall health.
perimenopause-and-weight-gain
Does everyone gain the same amount during perimenopause?
No. Perimenopause weight gain varies significantly. Some women gain 5 pounds, others 20 or more, and some maintain their weight. Factors include genetics, starting weight, activity level, stress, sleep quality, and how dramatically hormones fluctuate. Your experience is unique to your body.
Is perimenopause weight gain different from regular aging weight gain?
Yes. While metabolism naturally slows with age, perimenopause weight gain has distinct characteristics. The hormonal shifts cause fat redistribution to the midsection, even if overall weight doesn't change dramatically. This abdominal weight gain pattern is specifically linked to declining estrogen and progesterone, not just aging.
perimenopause-and-weight-gain
Will the weight come off after menopause?
Perimenopause weight gain often stabilizes after menopause when hormones level out, but the weight doesn't automatically disappear. The metabolic and body composition changes that occur during perimenopause tend to persist. However, with consistent healthy habits, weight management becomes more predictable post menopause than during the fluctuating perimenopause years.
https://www.oova.life/blog/progesterone-supplementation-guide
Can I take progesterone if I'm breastfeeding?
Yes, progesterone is generally safe while breastfeeding and doesn't significantly affect milk supply. However, always discuss with your healthcare provider before starting any hormone supplementation while nursing.
https://www.oova.life/blog/progesterone-supplementation-guide
Is it safe to take progesterone throughout pregnancy?
Yes, when prescribed by your healthcare provider. Progesterone supplementation in early pregnancy is safe and can reduce miscarriage risk in women with low progesterone or a history of pregnancy loss. Most providers continue supplementation through the first trimester (weeks 10-12) when the placenta takes over.
https://www.oova.life/blog/progesterone-supplementation-guide
Can progesterone supplementation cause weight gain?
Progesterone can cause temporary water retention and bloating, which may show up as a few pounds on the scale, but it doesn't cause true fat weight gain. Most women don't experience significant weight changes from progesterone supplementation.
https://www.oova.life/blog/progesterone-supplementation-guide
Can I switch from pills to suppositories or vice versa?
Yes, but only under your doctor's guidance. The dosing and timing may need adjustment when switching between forms since they're absorbed differently. Never switch on your own, especially if you're pregnant or undergoing fertility treatment.
https://www.oova.life/blog/progesterone-supplementation-guide
Will progesterone supplementation delay my period?
Yes, progesterone keeps the uterine lining intact, so if you're not pregnant and continue taking progesterone, your period will be delayed. Once you stop taking it, your period should start within 2-10 days. If you are pregnant, progesterone helps maintain the pregnancy and you won't get a period.
https://www.oova.life/blog/progesterone-supplementation-guide
Should I take progesterone pills orally or vaginally?
For fertility and pregnancy support, vaginal progesterone is usually preferred because it delivers higher concentrations directly to the uterus. For perimenopause or general hormone balance, oral progesterone often works well and is more convenient. Your doctor will recommend the best route based on your specific needs.
https://www.oova.life/blog/progesterone-supplementation-guide
When should I start taking progesterone after ovulation?
Typically, progesterone supplementation for luteal phase support starts 2-3 days after ovulation (confirmed by LH surge or temperature rise). Your doctor will give you specific timing based on your protocol. Some women start immediately after a positive ovulation test.
https://www.oova.life/blog/progesterone-supplementation-guide
What's better: progesterone cream or pills?
Pills (oral micronized progesterone) are generally more effective and reliable than creams because absorption from creams is inconsistent. For medical conditions like fertility issues, low progesterone, or HRT, prescription pills or suppositories are strongly recommended over over-the-counter creams.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
How can I tell if I have low or high progesterone?
The only definitive way to know is through hormone testing via blood tests or at-home urine tests that measure progesterone metabolites. However, symptom patterns can provide clues: anxiety and irregular periods suggest low progesterone, while bloating and extreme fatigue suggest high progesterone.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
When during my cycle should I test progesterone levels?
Test progesterone levels during the luteal phase, typically 7 days after ovulation or around day 21 of a 28-day cycle. This is when progesterone should be at its peak, making it easier to identify if levels are too low or too high.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
What are the main differences between low and high progesterone symptoms?
Low progesterone typically causes irregular or heavy periods, anxiety, hot flashes, and sleep issues. High progesterone causes bloating, fatigue, intense breast tenderness, and depression-like mood changes. Low progesterone symptoms persist throughout your cycle, while high progesterone symptoms are most intense during the luteal phase.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
Can you have symptoms of both low and high progesterone?
Some symptoms like breast tenderness and mood changes can occur with both low and high progesterone, making it confusing. However, the timing, intensity, and accompanying symptoms differ. Hormone testing is the best way to determine which imbalance you're experiencing.
https://www.oova.life/blog/10-dpo
Can stress affect 10 DPO symptoms?
Yes, stress can worsen or mimic 10 DPO symptoms. Stress increases cortisol, which can cause cramping, fatigue, and mood changes similar to both PMS and early pregnancy. During the two-week wait, try stress-reduction techniques like gentle exercise, meditation, or spending time with loved ones.
https://www.oova.life/blog/10-dpo
Is it better to test at 10 DPO or wait?
It's better to wait until 12–14 DPO for more accurate results. Testing at 10 DPO often leads to false negatives because hCG levels may still be too low. If you absolutely can't wait, use a sensitive early detection test with first morning urine, and be prepared to retest in 2–3 days if negative.
https://www.oova.life/blog/10-dpo
What does implantation bleeding look like at 10 DPO?
Implantation bleeding at 10 DPO is typically light pink or brown, much lighter than a period, and lasts 1–2 days. It's often just spotting when you wipe or a few drops on a panty liner. However, only 15–20% of pregnant women experience implantation bleeding—most don't have any bleeding at all.
https://www.oova.life/blog/10-dpo
Why am I cramping at 10 DPO?
Cramping at 10 DPO can be caused by elevated progesterone (whether you're pregnant or not), implantation (if you're pregnant), or premenstrual cramping. Unfortunately, cramping alone can't tell you if you're pregnant since progesterone causes similar symptoms in both scenarios.
https://www.oova.life/blog/10-dpo
What are the chances of a BFP at 10 DPO?
If you're pregnant, you have about a 50–60% chance of getting a positive test at 10 DPO. This means there's a 40–50% chance of a false negative even if you conceived. Chances improve significantly by 12–14 DPO.
https://www.oova.life/blog/10-dpo
What DPO is most accurate for pregnancy testing?
14 DPO (the day of your missed period) is the most accurate time to test, with 99% accuracy. 12 DPO offers 80–90% accuracy. 10 DPO has only 50–60% accuracy. For best results, wait as long as you can—ideally until 12–14 DPO.
https://www.oova.life/blog/10-dpo
Is 10 DPO too early to test?
10 DPO is considered early for pregnancy testing. While some women get positives at 10 DPO, accuracy is only 50–60% if you're pregnant. For best results, wait until 12 DPO (80–90% accuracy) or 14 DPO/missed period (99% accuracy).
https://www.oova.life/blog/10-dpo
Can you have implantation at 10 DPO?
Yes, implantation can still occur at 10 DPO, though 84% of women have already implanted by this point. Late implantation at 10–12 DPO is normal. If implantation happens at 10 DPO, you won't get a positive pregnancy test for another 2–3 days.
https://www.oova.life/blog/10-dpo
What does a negative test at 10 DPO mean?
A negative test at 10 DPO does not mean you're not pregnant. It's very common to get negatives at 10 DPO even if you conceived. Your hCG levels may still be too low, or implantation may have occurred later. Wait until 12–14 DPO to retest for more accurate results.
https://www.oova.life/blog/10-dpo
Can you get a positive pregnancy test at 10 DPO?
Yes, but only about 50–60% of pregnant women will get a positive at 10 DPO. The other 40–50% have hCG levels that are still too low to detect. If you test negative at 10 DPO, wait 2–3 days and test again.
https://www.oova.life/blog/high-progesterone-symptoms
Can high progesterone cause weight gain?
Yes, elevated progesterone can cause temporary weight gain through water retention and bloating. This is a normal part of the luteal phase and early pregnancy.
https://www.oova.life/blog/how-to-increase-estrogen
Does stress affect estrogen levels?
Yes, chronic stress elevates cortisol, which can suppress estrogen production and disrupt hormonal balance. Stress reduction through meditation, yoga, adequate sleep, and self-care practices helps maintain optimal estrogen levels.
https://www.oova.life/blog/how-to-increase-estrogen
When should I consider medical treatment for low estrogen?
Consider medical intervention if natural methods don't improve symptoms after 3 months, if symptoms severely impact quality of life, if you're experiencing early menopause (before 40), or if you have fertility concerns. Hormone replacement therapy may be appropriate in these cases.
https://www.oova.life/blog/how-to-increase-estrogen
What are the signs that my estrogen is increasing?
Signs of rising estrogen include more regular menstrual cycles, reduced hot flashes, improved vaginal lubrication, better mood stability, increased energy, and improved skin elasticity. You may also notice reduced symptoms that originally indicated low estrogen.
https://www.oova.life/blog/how-to-increase-estrogen
Can exercise increase estrogen levels?
Yes, moderate exercise stimulates estrogen release and helps maintain hormonal balance. Aim for 150 minutes of moderate cardio weekly plus strength training twice per week. However, excessive exercise can actually lower estrogen, so balance is key.
https://www.oova.life/blog/how-to-increase-estrogen
How long does it take to increase estrogen naturally?
With consistent dietary and lifestyle changes, you may notice improvements in symptoms within 4-8 weeks. However, significant hormonal changes typically take 2-3 months. Tracking your cycle and symptoms can help you monitor progress.
https://www.oova.life/blog/how-to-increase-estrogen
What foods increase estrogen levels naturally?
Foods high in phytoestrogens can help increase estrogen naturally. The best options include flax seeds (high in lignans), soy products (tofu, tempeh, edamame), lentils, chickpeas, whole grains (oats, quinoa, brown rice), and garlic. These plant compounds mimic estrogen's effects in the body.
https://www.oova.life/blog/perimenopause
What helps relieve hot flashes quickly?
Cool environments, layered clothing, herbal teas, and medical treatments like gabapentin or HRT may help—depending on severity. Lifestyle changes like reducing caffeine and alcohol can also provide relief.
https://www.oova.life/blog/perimenopause
Are there tests to confirm perimenopause?
Yes. Tests measuring estradiol, LH, and FSH levels can indicate hormonal shifts—but diagnosis is often symptom-based since hormone levels fluctuate widely during perimenopause.
https://www.oova.life/blog/perimenopause
How do I know it's perimenopause and not something else?
A doctor may recommend hormone testing (like LH, E3G, and PdG) and track symptom timing. Diagnosis is often based on symptoms combined with age and menstrual pattern changes.
https://www.oova.life/blog/perimenopause
What's the earliest age perimenopause can start?
Some women begin experiencing symptoms as early as their mid-30s, though perimenopause typically starts between ages 38-45.
https://www.oova.life/blog/perimenopause
Does perimenopause affect mental clarity?
Yes. Brain fog and difficulty concentrating are common during hormone fluctuations in perimenopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
What happens after the last sign of perimenopause?
After your final period, you enter postmenopause. You'll need 12 consecutive months without a period to confirm menopause. Many symptoms gradually improve, though some like vaginal dryness may persist without treatment.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
When do perimenopause symptoms finally stop?
Some symptoms like brain fog improve after menopause, while others like hot flashes may continue for up to 10 years post-menopause. Vaginal symptoms often persist or worsen without treatment. Each person's timeline is different.
https://www.oova.life/blog/high-progesterone-symptoms
Is high progesterone a sign of pregnancy?
Yes, high progesterone is one of the earliest indicators of pregnancy. Progesterone levels rise significantly after conception to support the developing embryo and reach their peak during the third trimester.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
Can you still get pregnant in late perimenopause?
Yes, you can still get pregnant during perimenopause as long as you're having periods, even if they're infrequent. Continue using birth control until you've gone 12 consecutive months without a period and have officially reached menopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
Do symptoms get worse before perimenopause ends?
Yes, most perimenopause symptoms intensify in the final 1-2 years before menopause. Hot flashes peak around your final period, vaginal symptoms worsen, and mood changes increase. However, brain fog typically improves in late perimenopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
How long does late perimenopause last?
Late perimenopause typically lasts 1-3 years before your final period. However, the exact duration varies significantly from person to person. You've reached menopause after 12 consecutive months without a period.
https://www.oova.life/blog/high-progesterone-symptoms
What are the symptoms of high progesterone?
High progesterone symptoms include fatigue, bloating, breast tenderness, weight gain, anxiety, depression, headaches, and food cravings. During pregnancy, you may also experience increased nipple sensitivity and muscle aches.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
What are the first signs that perimenopause is ending?
The earliest signs include longer gaps between periods (60+ days), intensifying hot flashes that peak around your final period, and worsening vaginal dryness. These symptoms typically increase in late perimenopause before you reach official menopause.
https://www.oova.life/blog/high-progesterone-symptoms
When should I be concerned about high progesterone?
Consult a healthcare provider if you experience high progesterone symptoms outside your luteal phase when not pregnant, or if symptoms include severe pelvic pain, abnormal vaginal bleeding, or rapid weight gain while on hormone therapy.
https://www.oova.life/blog/high-progesterone-symptoms
How do you test progesterone levels?
Progesterone can be measured through blood tests at your doctor's office or at-home urine tests that measure PdG (a progesterone metabolite). Testing is typically done during the luteal phase, about 7 days after ovulation.

About the Oova Blog:
Our content is developed with a commitment to high editorial standards and reliability. We prioritize referencing reputable sources and sharing where our insights come from. The Oova Blog is intended for informational purposes only and is never a substitute for professional medical advice. Always consult a healthcare provider before making any health decisions.