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Beyond Surface-Level: How to Actually Address Collagen Loss During Menopause

Droplette
Droplette
The Oova Team
The Oova Team

Restore Your Skin's Collagen Production During Menopause: A Complete Guide

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Published:
Jun 4, 2025
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Published:
Jun 4, 2025
Est. Read Time:
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Restore Your Skin's Collagen Production During Menopause: A Complete Guide

Hormones
Perimenopause
Science
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Restore Your Skin's Collagen Production During Menopause: A Complete Guide

If you've noticed your skin looking different during perimenopause or menopause, you're definitely not imagining things and you're certainly not alone. While hot flashes and mood swings are commonly discussed, the dramatic impact on skin health often comes as a surprise. The culprit behind many of these changes? A significant decline in collagen production.

A Quick Primer on Collagen

Collagen is the most abundant protein in our skin, comprising over 90% of its dry weight and providing crucial structural integrity. But here's the startling reality: collagen production begins decreasing at a rate of 1-1.5% per year starting in our mid-20s. This gradual loss accelerates dramatically during perimenopause and menopause, with research showing that women lose approximately 30% of their skin collagen within the first five years after menopause begins.

This isn't just a cosmetic concern, it represents a fundamental shift in skin physiology directly linked to hormonal changes. Estrogen plays a vital role in stimulating collagen production by binding to fibroblast estrogen receptors, which directly activates these cells to produce collagen. As estrogen levels plummet during menopause, fibroblast activation decreases significantly, resulting in lower collagen levels and accelerated skin aging.

Why Collagen Supplementation Matters for Perceived Age

The visual cues that signal "aging" to others go beyond just wrinkles. Studies show that facial plumpness and skin luminosity are key factors in how we perceive age. A face with diminished volume and dull skin texture is typically perceived as older, regardless of wrinkles or other factors.

This is why addressing collagen loss becomes crucial for maintaining a youthful appearance. However, not all collagen supplementation approaches are created equal:

The Truth About Topical Collagen

Despite marketing claims, topical collagen products face a fundamental challenge: collagen molecules are simply too large to penetrate the skin's outer barrier. When applied topically, collagen remains on the skin's surface, providing temporary hydration but unable to replenish the structural collagen within the dermis where it's actually needed.

The Limitations of Oral Collagen

Oral collagen supplements have gained popularity, but they come with significant limitations. When ingested, collagen is broken down into amino acids and peptides during digestion. These building blocks enter the bloodstream, but there's no guarantee they'll be transported to the skin and reassembled into new collagen where needed. In fact, most are directed to other organs and tissues based on the body's prioritization.

While some studies show modest improvements in skin hydration and elasticity with oral supplementation, the effects are limited compared to more direct approaches.

Collagen's Essential Functions in Maintaining Youthful Skin

Understanding exactly what you're trying to restore helps explain why delivery method matters so much. Collagen serves two essential functions in maintaining youthful skin appearance:

1. Structural Support and Plumping

Collagen forms the scaffolding that gives skin its firmness, elasticity, and plumpness. It works with elastin to create the skin's supportive matrix, preventing sagging and maintaining facial contours. When collagen diminishes, the skin loses its structural integrity, leading to:

  • Loss of facial volume and definition
  • Deepening wrinkles and facial folds
  • Reduced skin elasticity and firmness

2. Skin Luminosity and Radiance

Beyond its structural role, collagen contributes significantly to skin's luminosity and radiant appearance. Healthy collagen levels help:

  • Create a smooth, even skin surface that reflects light optimally
  • Maintain proper skin hydration by supporting the skin barrier
  • Support a healthy skin cell turnover rate, preventing dullness
  • Provide the foundation for even pigmentation and skin tone

When collagen diminishes, both functions are compromised, resulting in skin that not only sags but also appears duller, less radiant, and shows increased signs of aging.

The Next Generation: Collagen Boosting Peptide Treatments

This is where innovative skincare technology like Droplette comes into play, transforming the way collagen-boosting peptides reach your skin. This revolutionary method offers several advantages:

  • Direct delivery: Peptides are delivered directly to the dermis where collagen production takes place
  • Targeted stimulation: Specific peptides like Palmitoyl Pentapeptide-4 signal fibroblasts to increase collagen synthesis
  • Enhanced absorption: Advanced delivery systems ensure the active ingredients reach their target
  • Sustained results: Stimulating your own collagen production creates longer-lasting improvements

Think of it as having a conversation with your skin cells, these advanced peptide treatments essentially tell your fibroblasts to get back to work creating the collagen your skin needs. Rather than trying to replace what's lost, you're reactivating your skin's own production capacity.

Here's what makes this approach so effective: instead of hoping ingredients will somehow make their way through your skin's natural barriers (spoiler alert: they usually don't), Droplette ensures they reach the dermal layer where your collagen-producing fibroblasts actually live and work.

The key to effective collagen treatments? Getting ingredients where they need to go. This is especially important during menopause when the skin barrier may become more compromised or irregular.

Tracking Your Hormones for Optimal Treatment Timing

Knowing precisely where you are in your hormonal journey can dramatically improve the effectiveness of collagen treatments. Tools like Oova, which track estrogen and hormone levels, provide valuable insights that dramatically improve treatment effectiveness:

Personalize your approach. Each woman's hormonal journey through menopause is unique. By tracking your patterns, you can identify your personal "collagen receptivity windows," periods when your skin's fibroblasts are most responsive to collagen-stimulating ingredients. Rather than following generic advice, you can time treatments when your skin is primed to respond.

Work with your body's rhythms. Even during menopause, your body maintains biological rhythms that affect skin function. Hormone tracking helps you synchronize treatments with these natural processes, potentially making your collagen treatments significantly more effective during specific hormonal windows.

By tracking your estrogen levels, you can identify optimal times for treatments when your skin's natural collagen synthesis machinery is most receptive to support.

So How Do I Boost My Skin's Collagen Production?

After understanding menopausal collagen loss, the logical question is: what can you actually do about it? Boosting collagen effectively requires addressing both delivery and timing. Traditional skincare often fails during menopause because ingredients don't reach the collagen-producing layer of your skin. Professional treatments like microneedling and advanced delivery systems like Droplette  help active ingredients reach the dermis where they can actually work.

Timing is equally crucial. Track your hormone levels with Oova to identify when your skin's collagen-producing machinery is most receptive to stimulation. Apply your most potent treatments during these "receptivity windows" when tracking shows higher relative estrogen levels. This hormone-synchronized approach dramatically improves results compared to random application.

Avoid ineffective approaches like topical whole collagen or relying solely on dietary supplements and support these external treatments internally: protect existing collagen with daily sun protection, reduce inflammation through diet and skincare, and discuss whether hormone therapy might be appropriate with your healthcare provider.

The beauty of combining hormone tracking with advanced delivery technology like Droplette is that you're finally working with your body's natural rhythms rather than against them—making every application count. By developing a comprehensive, data-driven approach tailored to your unique hormonal patterns rather than searching for a single miracle product, you can effectively counter menopausal collagen loss.

About the author

Droplette
Droplette is a technology company revolutionizing the skincare industry with its breakthrough device. We are driven by the belief that technology has the power to improve health and wellness, and we are dedicated to creating products and solutions that improve upon the way things have always been done, starting with skincare. Traditional topicals can only do so much. The Droplette device and capsules use our enhanced aerosol technology to deliver active ingredients under the skin - where they can actually work. Droplette was founded in 2017 by two MIT-trained engineers.
The Oova Team
The Oova Team consists of doctors, researchers, and content experts. We collaborate to bring you medically-backed resources to help support your hormone journey. Learn more about our team.

Sources

https://www.oova.life/blog/progesterone-supplementation-guide
Can I take progesterone if I'm breastfeeding?
Yes, progesterone is generally safe while breastfeeding and doesn't significantly affect milk supply. However, always discuss with your healthcare provider before starting any hormone supplementation while nursing.
https://www.oova.life/blog/progesterone-supplementation-guide
Is it safe to take progesterone throughout pregnancy?
Yes, when prescribed by your healthcare provider. Progesterone supplementation in early pregnancy is safe and can reduce miscarriage risk in women with low progesterone or a history of pregnancy loss. Most providers continue supplementation through the first trimester (weeks 10-12) when the placenta takes over.
https://www.oova.life/blog/progesterone-supplementation-guide
Can progesterone supplementation cause weight gain?
Progesterone can cause temporary water retention and bloating, which may show up as a few pounds on the scale, but it doesn't cause true fat weight gain. Most women don't experience significant weight changes from progesterone supplementation.
https://www.oova.life/blog/progesterone-supplementation-guide
Can I switch from pills to suppositories or vice versa?
Yes, but only under your doctor's guidance. The dosing and timing may need adjustment when switching between forms since they're absorbed differently. Never switch on your own, especially if you're pregnant or undergoing fertility treatment.
https://www.oova.life/blog/progesterone-supplementation-guide
Will progesterone supplementation delay my period?
Yes, progesterone keeps the uterine lining intact, so if you're not pregnant and continue taking progesterone, your period will be delayed. Once you stop taking it, your period should start within 2-10 days. If you are pregnant, progesterone helps maintain the pregnancy and you won't get a period.
https://www.oova.life/blog/progesterone-supplementation-guide
Should I take progesterone pills orally or vaginally?
For fertility and pregnancy support, vaginal progesterone is usually preferred because it delivers higher concentrations directly to the uterus. For perimenopause or general hormone balance, oral progesterone often works well and is more convenient. Your doctor will recommend the best route based on your specific needs.
https://www.oova.life/blog/progesterone-supplementation-guide
When should I start taking progesterone after ovulation?
Typically, progesterone supplementation for luteal phase support starts 2-3 days after ovulation (confirmed by LH surge or temperature rise). Your doctor will give you specific timing based on your protocol. Some women start immediately after a positive ovulation test.
https://www.oova.life/blog/progesterone-supplementation-guide
What's better: progesterone cream or pills?
Pills (oral micronized progesterone) are generally more effective and reliable than creams because absorption from creams is inconsistent. For medical conditions like fertility issues, low progesterone, or HRT, prescription pills or suppositories are strongly recommended over over-the-counter creams.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
How can I tell if I have low or high progesterone?
The only definitive way to know is through hormone testing via blood tests or at-home urine tests that measure progesterone metabolites. However, symptom patterns can provide clues: anxiety and irregular periods suggest low progesterone, while bloating and extreme fatigue suggest high progesterone.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
When during my cycle should I test progesterone levels?
Test progesterone levels during the luteal phase, typically 7 days after ovulation or around day 21 of a 28-day cycle. This is when progesterone should be at its peak, making it easier to identify if levels are too low or too high.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
What are the main differences between low and high progesterone symptoms?
Low progesterone typically causes irregular or heavy periods, anxiety, hot flashes, and sleep issues. High progesterone causes bloating, fatigue, intense breast tenderness, and depression-like mood changes. Low progesterone symptoms persist throughout your cycle, while high progesterone symptoms are most intense during the luteal phase.
https://www.oova.life/blog/low-vs-high-progesterone-symptoms
Can you have symptoms of both low and high progesterone?
Some symptoms like breast tenderness and mood changes can occur with both low and high progesterone, making it confusing. However, the timing, intensity, and accompanying symptoms differ. Hormone testing is the best way to determine which imbalance you're experiencing.
https://www.oova.life/blog/10-dpo
Can stress affect 10 DPO symptoms?
Yes, stress can worsen or mimic 10 DPO symptoms. Stress increases cortisol, which can cause cramping, fatigue, and mood changes similar to both PMS and early pregnancy. During the two-week wait, try stress-reduction techniques like gentle exercise, meditation, or spending time with loved ones.
https://www.oova.life/blog/10-dpo
Is it better to test at 10 DPO or wait?
It's better to wait until 12–14 DPO for more accurate results. Testing at 10 DPO often leads to false negatives because hCG levels may still be too low. If you absolutely can't wait, use a sensitive early detection test with first morning urine, and be prepared to retest in 2–3 days if negative.
https://www.oova.life/blog/10-dpo
What does implantation bleeding look like at 10 DPO?
Implantation bleeding at 10 DPO is typically light pink or brown, much lighter than a period, and lasts 1–2 days. It's often just spotting when you wipe or a few drops on a panty liner. However, only 15–20% of pregnant women experience implantation bleeding—most don't have any bleeding at all.
https://www.oova.life/blog/10-dpo
Why am I cramping at 10 DPO?
Cramping at 10 DPO can be caused by elevated progesterone (whether you're pregnant or not), implantation (if you're pregnant), or premenstrual cramping. Unfortunately, cramping alone can't tell you if you're pregnant since progesterone causes similar symptoms in both scenarios.
https://www.oova.life/blog/10-dpo
What are the chances of a BFP at 10 DPO?
If you're pregnant, you have about a 50–60% chance of getting a positive test at 10 DPO. This means there's a 40–50% chance of a false negative even if you conceived. Chances improve significantly by 12–14 DPO.
https://www.oova.life/blog/10-dpo
What DPO is most accurate for pregnancy testing?
14 DPO (the day of your missed period) is the most accurate time to test, with 99% accuracy. 12 DPO offers 80–90% accuracy. 10 DPO has only 50–60% accuracy. For best results, wait as long as you can—ideally until 12–14 DPO.
https://www.oova.life/blog/10-dpo
Is 10 DPO too early to test?
10 DPO is considered early for pregnancy testing. While some women get positives at 10 DPO, accuracy is only 50–60% if you're pregnant. For best results, wait until 12 DPO (80–90% accuracy) or 14 DPO/missed period (99% accuracy).
https://www.oova.life/blog/10-dpo
Can you have implantation at 10 DPO?
Yes, implantation can still occur at 10 DPO, though 84% of women have already implanted by this point. Late implantation at 10–12 DPO is normal. If implantation happens at 10 DPO, you won't get a positive pregnancy test for another 2–3 days.
https://www.oova.life/blog/10-dpo
What does a negative test at 10 DPO mean?
A negative test at 10 DPO does not mean you're not pregnant. It's very common to get negatives at 10 DPO even if you conceived. Your hCG levels may still be too low, or implantation may have occurred later. Wait until 12–14 DPO to retest for more accurate results.
https://www.oova.life/blog/10-dpo
Can you get a positive pregnancy test at 10 DPO?
Yes, but only about 50–60% of pregnant women will get a positive at 10 DPO. The other 40–50% have hCG levels that are still too low to detect. If you test negative at 10 DPO, wait 2–3 days and test again.
https://www.oova.life/blog/high-progesterone-symptoms
Can high progesterone cause weight gain?
Yes, elevated progesterone can cause temporary weight gain through water retention and bloating. This is a normal part of the luteal phase and early pregnancy.
https://www.oova.life/blog/how-to-increase-estrogen
Does stress affect estrogen levels?
Yes, chronic stress elevates cortisol, which can suppress estrogen production and disrupt hormonal balance. Stress reduction through meditation, yoga, adequate sleep, and self-care practices helps maintain optimal estrogen levels.
https://www.oova.life/blog/how-to-increase-estrogen
When should I consider medical treatment for low estrogen?
Consider medical intervention if natural methods don't improve symptoms after 3 months, if symptoms severely impact quality of life, if you're experiencing early menopause (before 40), or if you have fertility concerns. Hormone replacement therapy may be appropriate in these cases.
https://www.oova.life/blog/how-to-increase-estrogen
What are the signs that my estrogen is increasing?
Signs of rising estrogen include more regular menstrual cycles, reduced hot flashes, improved vaginal lubrication, better mood stability, increased energy, and improved skin elasticity. You may also notice reduced symptoms that originally indicated low estrogen.
https://www.oova.life/blog/how-to-increase-estrogen
Can exercise increase estrogen levels?
Yes, moderate exercise stimulates estrogen release and helps maintain hormonal balance. Aim for 150 minutes of moderate cardio weekly plus strength training twice per week. However, excessive exercise can actually lower estrogen, so balance is key.
https://www.oova.life/blog/how-to-increase-estrogen
How long does it take to increase estrogen naturally?
With consistent dietary and lifestyle changes, you may notice improvements in symptoms within 4-8 weeks. However, significant hormonal changes typically take 2-3 months. Tracking your cycle and symptoms can help you monitor progress.
https://www.oova.life/blog/how-to-increase-estrogen
What foods increase estrogen levels naturally?
Foods high in phytoestrogens can help increase estrogen naturally. The best options include flax seeds (high in lignans), soy products (tofu, tempeh, edamame), lentils, chickpeas, whole grains (oats, quinoa, brown rice), and garlic. These plant compounds mimic estrogen's effects in the body.
https://www.oova.life/blog/perimenopause
What helps relieve hot flashes quickly?
Cool environments, layered clothing, herbal teas, and medical treatments like gabapentin or HRT may help—depending on severity. Lifestyle changes like reducing caffeine and alcohol can also provide relief.
https://www.oova.life/blog/perimenopause
Are there tests to confirm perimenopause?
Yes. Tests measuring estradiol, LH, and FSH levels can indicate hormonal shifts—but diagnosis is often symptom-based since hormone levels fluctuate widely during perimenopause.
https://www.oova.life/blog/perimenopause
How do I know it's perimenopause and not something else?
A doctor may recommend hormone testing (like LH, E3G, and PdG) and track symptom timing. Diagnosis is often based on symptoms combined with age and menstrual pattern changes.
https://www.oova.life/blog/perimenopause
What's the earliest age perimenopause can start?
Some women begin experiencing symptoms as early as their mid-30s, though perimenopause typically starts between ages 38-45.
https://www.oova.life/blog/perimenopause
Does perimenopause affect mental clarity?
Yes. Brain fog and difficulty concentrating are common during hormone fluctuations in perimenopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
What happens after the last sign of perimenopause?
After your final period, you enter postmenopause. You'll need 12 consecutive months without a period to confirm menopause. Many symptoms gradually improve, though some like vaginal dryness may persist without treatment.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
When do perimenopause symptoms finally stop?
Some symptoms like brain fog improve after menopause, while others like hot flashes may continue for up to 10 years post-menopause. Vaginal symptoms often persist or worsen without treatment. Each person's timeline is different.
https://www.oova.life/blog/high-progesterone-symptoms
Is high progesterone a sign of pregnancy?
Yes, high progesterone is one of the earliest indicators of pregnancy. Progesterone levels rise significantly after conception to support the developing embryo and reach their peak during the third trimester.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
Can you still get pregnant in late perimenopause?
Yes, you can still get pregnant during perimenopause as long as you're having periods, even if they're infrequent. Continue using birth control until you've gone 12 consecutive months without a period and have officially reached menopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
Do symptoms get worse before perimenopause ends?
Yes, most perimenopause symptoms intensify in the final 1-2 years before menopause. Hot flashes peak around your final period, vaginal symptoms worsen, and mood changes increase. However, brain fog typically improves in late perimenopause.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
How long does late perimenopause last?
Late perimenopause typically lasts 1-3 years before your final period. However, the exact duration varies significantly from person to person. You've reached menopause after 12 consecutive months without a period.
https://www.oova.life/blog/high-progesterone-symptoms
What are the symptoms of high progesterone?
High progesterone symptoms include fatigue, bloating, breast tenderness, weight gain, anxiety, depression, headaches, and food cravings. During pregnancy, you may also experience increased nipple sensitivity and muscle aches.
https://www.oova.life/blog/TBD-10-symptoms-and-how-to-get-relief
What are the first signs that perimenopause is ending?
The earliest signs include longer gaps between periods (60+ days), intensifying hot flashes that peak around your final period, and worsening vaginal dryness. These symptoms typically increase in late perimenopause before you reach official menopause.
https://www.oova.life/blog/high-progesterone-symptoms
When should I be concerned about high progesterone?
Consult a healthcare provider if you experience high progesterone symptoms outside your luteal phase when not pregnant, or if symptoms include severe pelvic pain, abnormal vaginal bleeding, or rapid weight gain while on hormone therapy.
https://www.oova.life/blog/high-progesterone-symptoms
How do you test progesterone levels?
Progesterone can be measured through blood tests at your doctor's office or at-home urine tests that measure PdG (a progesterone metabolite). Testing is typically done during the luteal phase, about 7 days after ovulation.

About the Oova Blog:
Our content is developed with a commitment to high editorial standards and reliability. We prioritize referencing reputable sources and sharing where our insights come from. The Oova Blog is intended for informational purposes only and is never a substitute for professional medical advice. Always consult a healthcare provider before making any health decisions.